Inhibition of Bruton tyrosine kinase in patients with severe COVID-19 – Science

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Inhibition of Bruton tyrosine kinase in patients with severe COVID-19 – Science

Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation. Bruton tyrosine kinase (BTK) regulates macrophage signaling and activation. Acalabrutinib, a selective BTK inhibitor, was administered off-label to 19 …
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